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黄芩的作用与功效及其药理作用

发布时间:2016-02-26   问大夫  责任编辑:红豆

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黄芩,很多人都不是太熟悉,它是一种草本植物,对于热病高热烦渴,或肺热咳嗽等具有很好的功效,它还有很多功效,很多人都不了解,下面和小编一起来看看吧。

黄芩的形态特征

多年生草本;根茎肥厚,肉质,径达2厘米,伸长而分枝。茎基部伏地,上升,高30~120厘米,基部径2.5-3毫米,钝四棱形,具细条纹,近无毛或被上曲至开展的微柔毛,绿色或带紫色,自基部多分枝。

叶坚纸质,披针形至线状披针形,长1.5~4.5厘米,宽0.5~1.2厘米,顶端钝,基部圆形,全缘,上面暗绿色,无毛或疏被贴生至开展的微柔毛,下面色较淡,无毛或沿中脉疏被微柔毛,密被下陷的腺点,侧脉4对,与中脉上面下陷下面凸出;叶柄短,长2毫米,腹凹背凸,被微柔毛。

花序在茎及枝上顶生,总状,长7~15厘米,常再于茎顶聚成圆锥花序;花梗长3毫米,与序轴均被微柔毛;苞片下部者似叶,上部者远较小,卵圆状披针形至披针形,长4~11毫米,近于无毛。花萼开花时长4毫米,盾片高1.5毫米,外面密被微柔毛,萼缘被疏柔毛,内面无毛,果时花萼长5毫米,有高4毫米的盾片。花冠紫、紫红至蓝色,长2.3~3厘米,外面密被具腺短柔毛,内面在囊状膨大处被短柔毛;冠筒近基部明显膝曲,中部径1.5毫米,至喉部宽达6毫米;冠檐2唇形,上唇盔状,先端微缺,下唇中裂片三角状卵圆形,宽7.5毫米,两侧裂片向上唇靠合。雄蕊4,稍露出,前对较长,具半药,退化半药不明显,后对较短,具全药,药室裂口具白色髯毛,背部具泡状毛;花丝扁平,中部以下前对在内侧后对在两侧被小疏柔毛。花柱细长,先端锐尖,微裂。花盘环状,高0.75毫米,前方稍增大,后方延伸成极短子房柄。子房褐色,无毛。

小坚果卵球形,高1.5毫米,径1毫米,黑褐色,具瘤,腹面近基部具果脐。花期7-8月,果期8-9月。

黄芩的生理特性

多年生草本,野生于山顶、山坡、林缘、路旁等向阳较干燥的地方。喜温暖,耐严寒,成年植株地下部分在-35℃低温下仍能安全越冬,35℃高温不致枯死,但不能经受 40℃以上连续高温天气。耐旱怕涝,地内积水或雨水过多,生长不良,重者烂根死亡。排水不良的土地不宜种植,土壤以壤土和沙质壤土,酸碱度以中性和微碱性为好,忌连作。

黄芩的作用与功效

【功能与主治】

清热燥湿,泻火解毒,止血,安胎,降血压。用于湿温、暑温胸闷呕恶,湿热痞满,泻痢,黄疸,肺热咳嗽,高热烦渴,血热吐衄,痈肿疮毒,胎动不安。

黄芩片: 除去杂质,置沸水中煮10分钟,取出,闷透,切薄片,干燥;或蒸半小时,取出,切薄片,干燥(注意避免曝晒)。该品为类圆形或不规则形薄片,外表皮黄棕色至棕褐色,切面黄棕色或黄绿色,具放射状纹理。照上述[鉴别](1)、(2)项下试验,应显相同的结果;照上述[含量测定]项下的方法测定,含黄芩苷(C21H18O11)不得少于8.0%。

酒黄芩:取黄芩片,照酒炙法(附录Ⅱ D)炒干。该品为类圆形或不规则形薄片,外表皮棕褐色,切面黄棕色,呈放射状纹理,略带焦斑,中心部分有的呈棕色。照上述[含量测定]项下的方法测定,含黄芩苷不得少于8.0%。

【临床应用】

1.用于湿温发热、胸闷、口渴不欲饮,以及湿热泻痢、黄疸等症。对湿温发热,与滑石、白蔻仁、茯苓等配合应用;对湿热泻痢、腹痛,与白芍、葛根、甘草等同用;对于湿热蕴结所致的黄疸,可与茵陈、栀子、淡竹叶等同用。

2. 用于热病高热烦渴,或肺热咳嗽,或热盛迫血外溢以及热毒疮疡等。治热病高热,常与黄连、栀子等配伍;治肺热咳嗽,可与知母、桑白皮等同用;治血热妄行,可与生地、牡丹皮、侧柏叶等同用;对热毒疮疡,可与金银花、连翘等药同用。此外,该品又有清热安胎作用,可用于胎动不安,常与白术、竹茹等配合应用。

通过以上介绍,对黄芩的作用与功效也是有着很好的了解的,但是要注意的是,这样的药物在使用的时候,也是要注意一些方式方法,尤其是对它不了解的时候,都是不能随意的乱用,否则对自身健康的危害比较大,使得疾病不能治愈。

黄芩的药理作用

1.抗菌作用:黄芩煎剂100%浓度,平板法试验,对痢疾杆菌、伤寒杆菌、副伤寒杆菌、霍乱弧菌、大肠杆菌、变形杆菌、绿脓杆菌、葡萄球菌、溶血性琏球菌(aB)、肺炎双球菌、白喉杆菌等有抑制作用。黄芩煎剂试管法试验11280 浓度可抑制伤寒杆菌、溶血性链球菌a1640 浓度抑制溶血性链球菌B,肺炎双球菌及福氏痢疾杆菌、人结核杆菌H371320 浓度可抑制霍乱弧菌、志贺氏痢疾杆菌;180 浓度时宋内氏痢疾杆菌有抑制作用。黄芩醇浸液0.5g/ml005g/ml,用琼脂斜面培养,药液与培养基11 混合,对绿脓杆菌有抑制作用。黄芩醇浸液2g/ml浓度,平皿法试验对大肠杆菌、桔草杆菌、金黄色葡萄球菌有抑制作用。黄芩煎剂、醇提剂1g/ml浓度,用平板法试验时对脑膜炎球菌均有抑作用。

2.抗真菌作用:黄芩煎液,试管斜面法试验4%浓度抑制狗小牙胞菌及堇色毛癣菌,8%浓度抑制许兰氏黄癣菌,10%浓度抑制许兰氏黄癣菌蒙古变种,15%浓度抑制共心性毛癣菌及铁锈色毛癣菌。黄芩水浸剂13浓度在试管内对堇色毛癣菌、同心性毛癣菌,许兰氏黄癣菌、奥杜盎氏小芽胞癣菌、羊毛样小芽胞癣菌、红色表皮癣菌、KW、氏表皮癣菌、星形奴卡氏菌等有不同程度抑菌作用。

抗病毒作用:黄芩煎剂25-100%浓度,体外试验对乙型肝炎病毒DNA复制有抑制作用。

3.抗炎抗变态反应:黄芩70%乙醇提取物200500mg/kg 灌胃黄芩素、黄芩甙、汉黄芩素50100mg/kg 灌胃,可抑制醋酸引起的小鼠腹腔渗出增加,对48/80(一种化合物名称,Sigma 生产)引起的大鼠足肿也有抑制作用,黄芩70%乙醇提取物500mg/kg 灌胃,黄芩素、黄芩甙及汉黄芩素100mg/kg灌胃对大鼠佐剂性关节炎有抑制作用。黄芩水提物100200mg/kg 灌胃,对大鼠被动皮肤过敏反应(PCA)有抑制作用,但对氯化苦引起的小鼠接触皮炎(耳肿胀)无明显影响。

4.对中枢神经系统的作用:黄芩煎剂4g/kg 腹腔注射,对小鼠防御性条件反射可使阳性反射时延长,而对非条件反射及分化无影响,说明黄芩可加强皮层抑制过程。黄芩煎剂2g/kg,对伤寒混合疫苗致热家兔有解热作用。但也有报道黄芩水煎剂或酒浸剂5-9g/只灌胃,或2g/im,均不能证明黄芩对伤寒疫苗致热家兔有解热作用。

5.对心血管的作用:黄芩醇提液1g/kg静脉注射,可使麻醉犬血压下降。黄芩煎剂006g/kg 静脉注射,对麻醉犬有明显降压作用。黄芩素20mg/kg 静脉注射,可使麻醉犬血压下降40-50%。黄芩浸剂灌胃/kg 灌胃,3/天,连续4周,使慢性肾性高血压犬血压下降,心率变慢。黄芩甙2×10-4mol/l,在豚鼠离体主动脉条、肺动脉条、气管条及右心房均有竞争性的拮抗肾上腺素,去甲肾上腺素及多巴胺引起的收缩作用,也拮抗异丙肾上腺素舒张气管和增加右心房自发频率作用,提示黄芩甙对aB1B2 受体均有阻断作用。

6.抗血小板聚集及抗凝:黄芩素、汉黄芩素、千层纸素A、黄芩黄酮Ⅱ及白杨素(chrysin)于浓度10mM时,均可抑制胶原诱导的大鼠血小板聚集,白杨素对ADP诱导的血小板聚集也有抑制作用,黄芩素及汉黄芩素对花生四烯酸诱导的血小板聚集也有抑制作用,黄芩素及黄芩甙对凝血酶诱导的纤维蛋白原转化为纤维蛋白也抑制;黄芩素及黄芩甙2050mg/kg 灌胃,对内毒素诱导的大鼠弥漫性血管内凝血,可以防止血小板及纤维蛋白原含量的降低。

降血脂:黄芩水浸液10%2ml/只灌胃,连续给药7周,可使胆固醇喂饲的家兔血清胆固醇含量下降。黄芩素、黄芩甙100mg/kg 灌胃,可降低实验性高血脂大鼠玉米油-胆固醇-胆酸喂饲血清游离脂肪酸、甘油三酯及肝甘油三酯的含量,黄芩黄酮Ⅱ100mg/kg 灌胃,可降低血清总胆固醇及肝甘油三酯的含量,增加血清高密度脂蛋白-胆固醇(HDL-ch)的含量,汉黄芩素100mg/kg 灌胃,可防止肝甘油三酯的沉积并增加血清HDL-ch的含量。黄芩素、黄芩甙 100mg/kg 灌胃,对乙醇引起的高血脂大鼠,可降低肝总胆固醇、游离胆固醇及甘油三酯含量,汉黄芩素能降低血清甘油三酯的水平,黄芩素能增加血清HDL-ch含量。

7.其它作用:黄芩素1020mg/kg 静脉注射,对麻醉犬有利尿作用。黄芩煎剂4g/kg 灌胃,对大鼠半乳糖性白内障有防治作用,可延缓白内障的形成。黄芩甙对大鼠晶体醛糖还原酶有抑制作用,其ID50 1.81 × 10-3mg/ml。黄芩甙150mg/kg 灌胃,对链黑霉素引起的糖尿病大鼠血糖水平无明显下降,但红细胞山梨醇含量于治疗后显著降低,提示在动物体内也有抑制醛糖酶的作用,有可能用于糖尿病性并发症的防治。黄芩甙、黄芩素及汉黄芩素50-125μg/ml 对小鼠肝唾液酸酶有抑制作用。黄芩甙100mg/kg,葡萄糖醛酸43mg/kg皮下注射均可对抗士的宁引起的小鼠死亡,而甙元黄芩素无效,认为黄芩甙水解后的葡萄糖醛酸起的解毒作用。黄芩对PGs的代谢有较广泛的影响,水提物对PGs的生物合成有抑制作用。

看了本文,你是否对黄芩的作用与功效有了更深的了解。如果你出现了以上的那些症状(如热病高热烦渴,或肺热咳嗽等),可以试下黄芩的。

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